ClariFix Angle Right

cryotherapy device


Stryker's ClariFix device goes straight to the root of chronic rhinitis - the overactive nerves.

Using a minimally invasive treatment called cryotherapy, the ClariFix device applies precise, controlled freezing to target tissue under direct visualization.

When the cold temperature reaches the nerves, the nerve signals are temporarily interrupted, no longer telling the nose to drip, run, and swell.50

Instruction for use IFU LIBRARY Product catalog VIEW PDF

Woman suffers at work

Chronic rhinitis is a problem

  • 58 million Americans suffer from chronic rhinitis37
  • 1 in 7 allergic rhinitis patients say they receive little to no relief from medications51
  • Pharmacological interventions only manage symptoms and require daily use
  • Surgical neurectomy can be too invasive

Features and benefits

  • Minimally invasive treatment that can be performed under injected or local anesthesia40, 48
  • Efficient procedure for your preferred site of service
  • Utilizes cryotherapy, a technique that has a well-established safety profile in multiple therapies41-47
  • Safe, effective treatment with 3 out of 4 patients reporting improvement at 6 months in their chronic rhinitis symptoms40,48

ClariFix works to relieve chronic rhinitis symptoms

Durable decrease in symptoms

  • Statistically significant improvement in rhinitis symptoms over pretreatment through 270 days post-procedure40,48

Significant improvement

  • Nasal congestion and rhinorrhea subscores improved significantly at all time points40,48
  • Both allergic and non-allergic rhinitis subcohorts showed improvement (p<0.001)48
  • Statistically and clinically significant improvements in all Rhinoconjunctivitis Quality of Life Questionnaire categories48


  • Most patients see improvement within four weeks after treatment40,48

Watch and learn about ClariFix

Doctors can use ClariFix cryotherapy in their preferred site of service. The physician places the device and a nasal endoscope into the back of the patient’s nose, where the overactive nerves are located.

Leveraging a proven technology

Cryotherapy has been well-established in medical literature as safe for soft tissue and nerve ablation.41-47

How cryotherapy works

The freezing cold temperature destroys or ablates the targeted tissue, relieving symptoms of rhinitis.40,48 The area of maximal cryotherapy injury is adjacent to the the ClariFix device's cryoprobe. The freeze penetration zone grows slowly at an average rate of 1mm every 17 seconds.49

Collagen fibers are resistant to freeze injury and are not subject to the denaturation and contraction that can result from other, thermal-based tissue destruction modalities. Preservation of the extracellular matrix and the architecture of nerves, larger blood vessels, and bone provide a scaffold for tissue repair, enabling good tissue healing.41-47