Histology
Histology findings confirming LATERA® absorbable nasal implant replaced with supportive tissue over 18-24 months.
Study
Overview
An animal study examining the biocompatibility and absorption profile of LATERA absorbable nasal implant was published in Laryngoscope. Histologic findings are based on implants placed in the Nasal Dorsum (Ovine model), from 6 weeks through 24 months.
Implantation
Implant integrity maintained while fibrous capsule forms.
Encapsulation
Tissue encapsulation promotes acute implant stability. Safety profile shows minimal inflammatory response and expected surrounding tissue reaction.
Remodeling
Capsule and fibrotic tissue remains as implant degrades and is absorbed.
Collagen construct replaces implant at 24 months.
Featured publication
Rippy MK, Baron S, Rosenthal M, Senior BA. Evaluation of absorbable PLA nasal implants in an ovine model. Laryngoscope Investig Otolaryngol. 2018 May 25;3(3):156-161. https://onlinelibrary.wiley.com/doi/full/10.1002/lio2.166
Nasal airway obstruction
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